Neural Mechanisms
Separating Therapeutic Effects from Hallucinations
Groundbreaking research identifies distinct neural circuits for anxiety reduction versus perceptual effects,
potentially enabling therapeutic benefits without intense hallucinations.
2025
ScienceDaily
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Clinical Trials
Expanding Psychedelic Applications Beyond Depression
Major institutions launch trials for opioid addiction, Alzheimer's, PTSD, anorexia nervosa,
Parkinson's, chronic pain, and post-treatment Lyme disease syndrome.
2025
Johns Hopkins & UCSF
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Neuroplasticity
Understanding Psychedelic-Induced Brain Changes
New insights into how psychedelics promote structural, functional, and molecular neuroplasticity,
with effects persisting weeks after a single dose.
2025
arXiv & The Guardian
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Novel Compounds
5-MeO-DMT Shows Promise for Treatment-Resistant Depression
Phase 2b trial demonstrates significant depression score reductions and high remission rates
with tolerable side effects in TRD patients.
2025
Clinical Trial Results
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Drug Development
Bretisilocin: A Novel Serotonergic Psychedelic
DMT-related compound in Phase 2 trials shows high remission rates for major depressive disorder,
attracting major pharmaceutical investment.
2025
AbbVie/Reuters
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Non-Hallucinogenic
DLX-159: Psychoplastogen Without Perceptual Effects
Delix Therapeutics develops rapidly-acting antidepressant that promotes neuroplasticity
without hallucinogenic properties in preclinical models.
2025
Delix Therapeutics
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Cancer Care
Long-Term Benefits of Psilocybin in Cancer Patients
Single psilocybin session produces years-long improvements in depression and anxiety
for cancer patients, with many requiring no further treatment.
2025
PsyPost
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Industry & Regulation
Pharmaceutical Investment and FDA Challenges
Major pharmaceutical deals signal industry confidence while regulatory concerns
about data and ethics continue to shape the approval landscape.
2025
Reuters & Pharmacy Times
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